The Japanese movie titled Lupin III: The Mystery of Mamo and directed by Soji Yoshikawa was released in 1978 and is categorized as anime.
Key cast members of Lupin III: The Mystery of Mamo include Yasuo Yamada.
The plot of Lupin III: The Mystery of Mamo is: Inspector Zenigata travels to Castle Dracula to confirm the execution of his longtime nemesis Arsène Lupin III; the body he finds is a decoy that is being used by another Lupin to flee from the castle. Zenigata travels to Egypt, believing that Lupin will raid the Giza Necropolis based on prior thefts of immortality-granting objects. His prediction proves accurate, but Lupin and his colleagues Daisuke Jigen and Goemon Ishikawa XIII flee with the Philosopher's Stone. The Stone was requested by Lupin's would-be lover, Fujiko Mine, who, having agreed to obtain the Stone for a mysterious client, steals it from Lupin in Paris. The benefactor reveals his name to her as Mamo, but they discover that the Stone is a fake made by Lupin.
In response, Lupin's gang is attacked by Mamo's forces before finding their hideout destroyed by his henchman, Flinch. Jigen and Goemon blame the hideout's destruction on Fujiko, before quarrelling between themselves; Lupin calms the others by promising to abandon his desires for Fujiko. With nowhere else to go, they travel toward the ocean before finding a house with food and water. A wounded Fujiko comes for Lupin, forcing him to go against his promise and causing Jigen and Goemon to abandon them. Fujiko drugs Lupin before Flinch arrives to take them to Mamo. Jigen later returns to find the plane leaving, but retrieves a clue to its destination. He and Goemon are later interrogated about Mamo by American agents, but are released when they are unable to answer their questions. During the inquiry, they decipher Fujiko’s clue, leading them to the Caribbean.
On a Caribbean island, Mamo, a mysterious billionaire officially known as Howard Lockewood, tells Lupin that he manipulated him into stealing the Stone as a test, as he is considering granting him and Fujiko immortality in admiration of their skills. Lupin, however, is more interested in the Stone, and searches Mamo's island for it. After retrieving the Stone, he and Fujiko are chased by Mamo's henchmen until they stumble across Mamo's lair. Mamo deems Lupin unworthy of eternal life and attempts to visualize his perverted nature to Fujiko, but she refuses to abandon him. The USAF attacks the base, having tracked Jigen and Goemon to the island. Jigen rescues Lupin and Fujiko and seemingly kills Mamo in a shootout, while Goemon duels with Flinch. The altercation damages Goemon's sword, the Zantetsuken, causing him to leave for training purposes.
Lupin, Fujiko and Jigen travel to Colombia, where Lupin theorizes that Mamo may have gained eternal life by continuously cloning himself. They are thrust into a vision by Mamo, who reveals that his cloning technique has kept him alive for ten thousand years, and that he is responsible for virtually every major event in human history. Mamo also explains that he cloned Lupin. He then appears in person to reclaim Fujiko, and a distraught Lupin challenges him to perform a miracle. Mamo responds by setting off an earthquake through the destruction of a nuclear power station.
Inside a temple, Mamo explains to Fujiko that his cloning technique has never been perfected, and that he has degenerated from his original form as a result. He decides that he and Fujiko must repopulate the Earth, and convinces her to push a button to launch nuclear missiles to achieve this end. Lupin arrives, and reveals that he rigged the missiles to explode before they could launch. Frustrated, Mamo takes Fujiko with him to a launching pad and fends Lupin off with lasers. Lupin uses the tip of Goemon's sword (given to him by Jigen earlier) to deflect the lasers, incinerating Mamo.
A rocketship emerges, containing a giant brain that reveals itself to be the original Mamo. Lupin realizes that Mamo had controlled his clones resembling his body just as the rocket launches into space. Lupin and Fujiko escape the rocket's trajectory, but not before Lupin plants an explosive on it. The glass shatters, and Mamo's brain drifts toward the sun. Lupin finds Fujiko in the rubble, where he is captured by Zenigata. Fujiko offers to help Lupin, but the Americans launch a missile attack on Mamo's base. Fujiko is rescued by Jigen, while Lupin and Zenigata, handcuffed together, escape on foot..
