25782319
OBJECTIVE	To study effect of combined therapy with amlodipine with ramipril on the circadian profile of arterial pressure in patients with arterial hypertension in the Far North depending on the shiftwork regime .
METHODS	130 patients with grade 2-3 AH were divided into 2 groups depending on the work-time schedule .
METHODS	Group 1 included 67 daywork patients group 2 consisted of 63 patients working in the alternating daywork and nightwork regime .
METHODS	24 hr AH monitoring was performed before , 4 weeks and 6 months after the onset of the study .
RESULTS	Six months after the onset of therapy practically all patients reached the target AD level ( 94.4 % in group 1 and 94.7 % in group ) .
RESULTS	The patients fairly well tolerated therapy AD circadian profile was normalized 1.9 times in group 1 and 3.2 times in group 2 .
RESULTS	Recovered AP variability in group 1 resulted in a decreased frequency of target organ affection .
RESULTS	In group 2 , the initially higher variability accounted for the normalization of only diastolic AP variability after 6 month therapy .
RESULTS	It suggests the necessity of prescription of a third anti-AH preparation to these patients .
RESULTS	Morning AP dynamics improved in both groups .

