25617561
BACKGROUND	Inflammation is one of the main contributory factors to the etiopathogenesis of multiple sclerosis ( MS ) .
BACKGROUND	Dietary interventions with Lipia citriadora ( lemon verbena ) extracts have been proved to be effective in the prevention of inflammatory diseases .
OBJECTIVE	The aim of this study is to evaluate the effect of lemon verbena supplementation in pro- and anti- inflammatory serum biomarkers of patients with different clinical subtypes of multiple sclerosis .
METHODS	The effect of lemon verbena supplementation ( 10 % w/w verbascoside ) was evaluated in a randomized , double-blinded placebo-controlled study with 30 participants classified in relapsing-remitting ( n = 10 ) , primary progressive ( n = 5 ) and secondary progressive ( n = 15 ) MS presentations .
METHODS	Serum cytokine and C reactive protein levels were assessed in intervention and control groups for each MS clinical subtype after 28 days of dietary supplementation .
RESULTS	Serum levels of C reactive protein and 8 cytokines / inflammatory ( IFN - , IL-12 , IL-23 , IL-6 , TNF - , TGF - , IL-4 and IL-10 ) markers were studied .
RESULTS	Secondary progressive MS - supplemented patients showed C reactive protein concentrations significantly lower compared to the placebo group ( p.

