25426896
OBJECTIVE	To evaluate the effect of ozonated oil on palatal wounds .
METHODS	Eighteen patients were randomized and allocated to either the ozone group ( n = 8 ) or control ( n = 10 ) group .
METHODS	Free gingival graft surgery was performed , and post-harvested palatal wounds were treated with either 2 mL ozonated oil or control oil daily for 1 week .
METHODS	A planimetrical analysis analyzed the digital image for the wound sizes and shape factor at baseline , at 24 h , and days 5 , 7 , 14 , 21 , and 28 , postoperatively .
METHODS	A cytological analysis used the keratinization and superficial cell indices at baseline , 24 h , and days 3 , 7 , 14 , and 21 and the second and third months , postoperatively .
RESULTS	Planimetrical results showed a significant ( P 0.05 ) improvement in wound size on days 5 , 7 , 14 , 21 , and 28 , postoperatively , in the ozone group compared to the control group .
RESULTS	Cytological results showed a significant ( P 0.001 ) improvement in epithelial healing on days 7 , 14 , and 21 , and the second and third months , postoperatively , after the application of ozonated oil compared to control oil .
CONCLUSIONS	Our results showed significant improvement in wound size and epithelial healing after topical ozonated oil application compared to control oil on palatal wounds .

