25335329
OBJECTIVE	To study the effect of Shugan Jiangu Recipe ( SJR ) on bone mineral density ( BMD ) and serum bone metabolic biochemical markers in postmenopausal breast cancer patients with osteopenia .
METHODS	Totally 38 patients of postmenopausal women with breast cancer , who received aromatase inhibitors ( AIs ) , were assigned to the treatment group ( 21 cases ) and the control group ( 17 cases ) by using random digit table .
METHODS	All patients took Caltrate D Tablet ( containing Ca 600 mg and Vit D3 125 IU ) , one tablet daily .
METHODS	Patients in the treatment group took SJR , 6 g each time , twice daily for 6 successive months .
METHODS	The bone mineral density ( BMD ) level was detected before treatment and at months 6 after treatment .
METHODS	Levels of bone alkaline phosphatase ( BALP ) , bone gla protein ( BGP ) , tartrate-resistant acid phosphatase ( TRAP ) , and C-terminal telopeptide of type II collagen ( CTX-II ) were detected by enzyme linked immunosorbent assay ( ELISA ) .
METHODS	The drug safety was also assessed .
RESULTS	Compared with before treatment , BMD of L2-4 and femur neck obviously increased in the treatment group at month 6 after treatment ( P < 0.01 ) , serum BALP and TRAP decreased ( P < 0.05 ) .
RESULTS	Compared with before treatment , BMD of L2-4 and femur neck obviously decreased in the control group at month 6 after treatment ( P < 0.05 ) , serum BALP and TRAP increased ( P < 0.01 ) .
RESULTS	Compared with the control group , lumbar and femur neck BMD obviously increased , serum levels of BGP and BALP obviously decreased , and serum levels of CTX-II and TRAP obviously increased in the treatment group at month 6 after treatment ( P < 0.01 ) .
RESULTS	No serious adverse event occurred during the treatment period .
RESULTS	Bone fracture occurred in one case of the control group ( 5.8 % ) .
CONCLUSIONS	SJR could attenuate bone loss of postmenopausal women with breast cancer who received AIs , increase BMD and improve abnormal bone metabolism .

