25167350
BACKGROUND	One of the most challenging aspects of a revision knee arthroplasty is the management of bone loss .
BACKGROUND	The OBJECTIVE of the study is to show the capability to augment bone mineral density in areas with bone loss with platelet-derived growth factors .
METHODS	Randomized , prospective , blinded study in patients who underwent a total knee replacement revision with tibial-damaged metaphyseal bone were randomly allocated to have a revision total knee arthroplasty and to fill the bone defects with lyophilized bone allograft mixed with platelet growth factors ( experimental group , n = 9 ) or with lyophilized bone allograft alone ( control group , n = 7 ) .
METHODS	To evaluate bone mineral density between groups , dual-energy X-ray absorptiometry ( DEXA ) was performed preoperatively , at 1 month , 6 months and 1 year after surgery .
RESULTS	The study was comprised of a total of 16 patients .
RESULTS	We found no significant differences observed during the follow-up between groups in mineral bone density .
CONCLUSIONS	Use of platelet-derived growth factors does not improve bone mineral density in patients with revision knee arthroplasty .

