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OBJECTIVE	The purpose of the study was to analyze the potential capacity of a dietary supplement , based on gamma linolenic acid , vitamin E , vitamin C , beta-carotene , coenzyme Q10 and Vitis Vitifera , to reduce side effects , in particular the dry skin , erythema and desquamation , due to treatment with oral isotretinoin , and evaluate the ability of the product to increase adherence to therapy in patients with acne .
METHODS	Forty-eight patients with nodular acne ( 32 females and 16 males ) were randomly divided into 2 groups : 24 received isotretinoin therapy ( 20-30 mg/day ) for 6 months associated to dietary supplement ( twice a day ) , while the other 24 patients received only isotretinoin ( 20-30 mg/day ) for 6 months .
METHODS	For all patients the degree of acne severity , through GAGS ( Global Acne Grading System ) , the sebum production by Sebutape , the hydration by Corneometer and the erythema by Mexameter , were measured .
METHODS	We have also evaluated the adherence to treatment , asking to patients how many days a week they follow the therapy .
RESULTS	Patients treated with dietary supplement had lower side effects , with a less degree of erythema and dryness , and greater degree of hydration ; a greater adherence to therapy was also reported .
CONCLUSIONS	Thanks to antioxidant and moisturizing properties , the dietary supplement containing gamma linolenic acid , vitamin E , vitamin C , betacarotene , coenzyme Q10 and Vitis Vitifera , can be considered a useful supplement in the treatment and prevention of dry skin associated with the use of oral isotretinoin .

