24564308
OBJECTIVE	To evaluate the cardiorespiratory effects of IV administration of propofol ( 4 mg/kg ) , ketamine hydrochloride and propofol ( 2 mg/kg each ; K-P ) , or ketamine hydrochloride ( 5 mg/kg ) and diazepam ( 0.2 mg/kg ; K-D ) before and after induction of anesthesia ( IoA ) in dogs sedated with acepromazine maleate and oxymorphone hydrochloride .
METHODS	10 healthy adult Beagles .
METHODS	Each dog was randomly allocated to receive 2 of 3 treatments ( 1-week interval ) .
METHODS	For instrumentation prior to each treatment , each dog was anesthetized with isoflurane .
METHODS	After full recovery , acepromazine ( 0.02 mg/kg ) and oxymorphone ( 0.05 mg/kg ) were administered IV .
METHODS	Fifteen minutes later ( before IoA ) , each dog received treatment IV with propofol , K-P , or K-D .
METHODS	Cardiorespiratory and arterial blood gas variables were assessed before , immediately after , and 5 minutes after IoA .
RESULTS	Compared with findings before IoA , dogs receiving the K-P or K-D treatment had increased cardiac output , oxygen delivery , and heart rate 5 minutes after IoA ; K-P administration did not change mean arterial blood pressure or stroke volume and decreased systemic vascular resistance .
RESULTS	Propofol decreased mean arterial blood pressure and systemic vascular resistance immediately after IoA but did not change heart rate , cardiac output , or oxygen delivery .
RESULTS	All treatments caused some degree of apnea , hypoventilation , and hypoxemia ( Pao2 < 80 mm Hg ) .
CONCLUSIONS	In dogs , K-P treatment maintained mean arterial blood pressure better than propofol alone and increased heart rate , cardiac output , or oxygen delivery , as did the K-D treatment .
CONCLUSIONS	Supplemental 100 % oxygen should be provided during IoA with all 3 treatments .

