24596005
OBJECTIVE	The aim of this study is to evaluate the effects of hormone replacement therapy using dienogest and medroxyprogesterone acetate on psychological symptoms in perimenopausal and postmenopausal women .
METHODS	A total of 73 patients who sought treatment at the menopause units of the authors ' gynecology and obstetrics clinics between of November 2003 and October 2004 complaining of vasomotor symptoms were included in the study prospectively .
METHODS	The cases were divided into two groups : Group I ( 37 patients ) was given 2 mg estradiol valerate and 2 mg dienogest , and Group II ( 36 patients ) was given 2 mg estradiol valerate and 10 mg medroxyprogesterone acetate .
METHODS	The groups ' results in months 0 and 6 were compared through the evaluation of vasomotor and psychological symptom levels .
RESULTS	No significant difference was found between the groups when the initial levels of vasomotor and psychological symptom subtypes were compared ( p = 0.16 ) .
RESULTS	It was observed that all the psychological symptoms decreased in the 6th month in the group using dienogest in comparison with the initial situation , and that psychological symptoms increased in the group using medroxyprogesterone acetate in the evaluation performed in the 6th month compared with the initial levels .
RESULTS	It was also found out that there was a statistically significant difference between the two groups when compared in terms of these symptoms ( p < 0.0001 ) .
CONCLUSIONS	While the use of dienogest normalizes the general psychological situation and sleep , it was observed that the use of medroxyprogesterone acetate ( MPA ) worsens the general psychological situation .

