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OBJECTIVE	A recently published study showed the safety and efficacy of LSD-assisted psychotherapy in patients with anxiety associated with life-threatening diseases .
OBJECTIVE	Participants of this study were included in a prospective follow-up .
METHODS	12 months after finishing LSD psychotherapy , 10 participants were tested for anxiety ( STAI ) and participated in a semi-structured interview .
METHODS	A Qualitative Content Analysis ( QCA ) was carried out on the interviews to elaborate about LSD effects and lasting psychological changes .
RESULTS	None of the participants reported lasting adverse reactions .
RESULTS	The significant benefits as measured with the STAI were sustained over a 12-month period .
RESULTS	In the QCA participants consistently reported insightful , cathartic and interpersonal experiences , accompanied by a reduction in anxiety ( 77.8 % ) and a rise in quality of life ( 66.7 % ) .
RESULTS	Evaluations of subjective experiences suggest facilitated access to emotions , confrontation of previously unknown anxieties , worries , resources and intense emotional peak experiences la Maslow as major psychological working mechanisms .
RESULTS	The experiences created led to a restructuring of the person 's emotional trust , situational understanding , habits and world view .
CONCLUSIONS	LSD administered in a medically supervised psychotherapeutic setting can be safe and generate lasting benefits in patients with a life-threatening disease .
CONCLUSIONS	Explanatory models for the therapeutic effects of LSD warrant further study .

