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OBJECTIVE	This study assessed the effects of systemic omega-3 on the treatment of recurrent aphthous stomatitis and on the improvement of quality of life .
METHODS	Fifty participants were randomly assigned to receive either omega-3 ( 1 g , 3 times daily ) or placebo for 6 months .
METHODS	Assessment of outcome measures including monthly number of new ulcers , average duration of ulcer episodes , and pain level of ulcers was carried out at baseline and monthly for 6 months .
METHODS	Analysis of potential impact on quality of life using the Oral Health Impact Profile 14 was carried out at baseline and 6 months .
RESULTS	Daily omega-3 treatment achieved a significant reduction in number of ulcers , duration of ulcers , and level of pain by 3 months that persisted for 6 months .
RESULTS	Mean score on Oral Health Impact Profile 14 also significantly improved by 6 months .
CONCLUSIONS	A daily omega-3 regimen shows promise as therapy for treatment and management of patients with recurrent aphthous stomatitis .

